NCRN Bladder Cancer Studies Open to Recruitment

Please note the portfolio will be updated on a monthly basis and includes open studies only. If you have any queries please contact the NISCHR CRC Information and Portfolio team        
An asterisk denotes that the study is open in at least one site in that region.

Study Name

Study Description

North Wales

South East Wales

South West Wales


FGFR Inhibition for Epithelial Solid Tumours: a Phase Ib trial of AZD4547 in combination with gemcitabine and cisplatin





Image Guided Dose Escalated Adaptive Bladder Radiotherapy





LaMB - a phase II/III, randomised, two-arm comparison of maintenance lapatinib versus placebo after first-line chemotherapy in patients with HER1 and/or HER2 overexpressing locally advanced or metastatic bladder cancer





A Randomised Phase II study investigating pazopanib vs weekly paclitaxel in relapsed or progressive Transitional Cell Carcinoma (TCC) of the urothelium.





A Phase III randomised trial of PeriOperative chemotherapy versus sUrveillance in upper Tract urothelial cancer




TOTEM: Trial of Temsirolimus for Advanced Urothelial Cancer

A Phase I/II single-arm trial to evaluate the combination of cisplatin and gemcitabine with the mTOR inhibitor temsirolimus for first-line treatment of patients with advanced transitional cell carcinoma of the urothelium.




TOUCAN (Bladder cancer)

Vandetanib in non-cisplatin fit patients with urothelial cancers - A randomised phase II Trial of carboplatin and gemcitabine +/- vandetanib in first line treatment Of advanced Urothelial cell Cancer in patients who are not suitable to receive cisplatin




Urine Biomarkers

Collection of urine specimens to study the possible presence of biomarkers of genitourinary cancer using novel enzyme substrates





Hospitals supported by the WCRN Research Networks:
North Wales Hospitals South East Wales Hospitals South West Wales Hospitals
Glan Clwyd, Rhyl Llandough Bronglais
Wrexham Maelor Nevill Hall Morriston
Ysbyty Gwynedd, Bangor Prince Charles
Neath Port Talbot
  Princess of Wales   Prince Phillip
  Royal Glamorgan  Singleton
  Royal Gwent and St Woolos West Wales General
  University Hospital of Wales
  Velindre Cancer Centre  

Last updated: 24/03/2014